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What are the signs and symptoms of Histoplasmosis?

Signs and Symptoms of histoplasmosis infection often occur within 3 to 17 days after exposure; the average is 12–14 days. Most affected individuals have clinically silent manifestations and show no apparent ill effects.[4] The acute phase of histoplasmosis is characterized by non-specific respiratory symptoms, often cough or flu-like. Chest X-ray findings are normal in 40–70% of cases.[4] Chronic histoplasmosis cases can resemble tuberculosis;[5][6] disseminated histoplasmosis affects multiple organ systems and is fatal unless treated.[7]While histoplasmosis is the most common cause of mediastinitis, this remains a relatively rare disease. Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement.[2] Lesions have a tendency to calcify as they heal.Presumed ocular histoplasmosis syndrome (POHS) causes chorioretinitis, where the choroid and retina of the eyes are scarred, resulting in a loss of vision not unlike macular degeneration. Despite its name, the relationship to Histoplasma is controversial.[8][9] Distinct from POHS, acute ocular histoplasmosis may rarely occur in immunodeficiency.[10][11] (Wikipedia)

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